Synthetic Protection Short Interfering RNA Screen Reveals Glyburide as a Novel Radioprotector
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چکیده
منابع مشابه
RNAi through short interfering RNA (siRNAs) as a Novel Therapeutic Strategy
Since RNA interference (RNAi) was discovered in the late 1990s, it has evolved as a powerful and widely used strategy for the efficient silencing of genes. RNAi relies on the action of small interfering RNAs (siRNAs) which are incorporated into a complex termed RNAinduced silencing complex (RISC) and guide RISC to its cleavage site on the target mRNA. Thus, the efficiency of RNAi in vitro and i...
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RNA silencing is a eukaryotic genome defence system that involves processing of double-stranded RNA (dsRNA) into 21-26 nt, short interfering RNA (siRNA). The siRNA mediates suppression of genes corresponding to the dsRNA through targeted RNA degradation. In some plant systems there are additional silencing processes, involving systemic spread of silencing and RNA-directed methylation/transcript...
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MOTIVATION Recent studies have demonstrated widespread adenosine-inosine RNA editing in non-coding sequence. However, the extent of editing in coding sequences has remained unknown. For many of the known sites, editing can be observed in multiple species and often occurs in well-conserved sequences. In addition, they often occur within imperfect inverted repeats and in clusters. Here we present...
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ژورنال
عنوان ژورنال: Radiation Research
سال: 2009
ISSN: 0033-7587
DOI: 10.1667/rr1674.1